This college was established by the Catholic Sisters' of Assumption Organization in 1934. The aim of establishing this college was to prepare female teachers so as to increase the number of female teachers in the country. The college started at Kilema Mission Center where Home Economics and Teaching courses were offered.

Due to insufficient area of Kilema Mission Centre for expansion, from 1957 to 1959, the college was relocated to a new area in Mandaka and named Mandaka Teachers College. The Assumption Sisters of the Catholic Church initiated this college and led it from 1934 to 1970.

In January 1970, the college was taken over by the Government of the United Republic of Tanzania and given registration number C.U.11 to continue training female Primary School Teachers at Certificate level. In 1996, the college began offering Diploma in Secondary Education specializing in Chemistry or Biology and Home Economics for two years. This college was so special in such from 1934 to 2013 trained female teachers only. However, in 2013, the college began preparing both male and female student teachers for Primary and Secondary Education.

Currently (from 2024/2025), the college has started offering Diploma in Primary Education specializing in Science and Mathematics using English as a language of instruction.